Friday, 28 November 2014

Update on research analysis

I've been keeping myself busy over the last few weeks. Back in 2013 I had downloaded all of the papers on the PubMed database which referenced HSP, but I hadn't really done anything with them. I've now undertaken two passes through the papers getting ready to put a more in depth analysis up on a new page.

I've limited myself to papers with abstracts - so I've got some better information on what information the paper contains, there are just over 1000 of those.

My first pass was to look through the papers and give them a "usefulness" rank. Papers which I thought would be very useful were given the rank of 10, with smaller numbers for papers which were less relevant. My "default" rank for papers on HSP which aren't obviously useful is 4, which allowed me to score lower than this for papers which mention HSP in passing rather than being specifically about HSP (or some aspect of this).

My second pass has been to read all of the abstracts again and divide the papers into categories. Evan Reid had indicated at the AGM in the summer that HSP research could be divided up into three zones, and I wanted to see what these zones looked like. I began with the papers which I had ranked 10, and then worked down the list until I got to rank 4, so there are some 800 papers which I've done this for.

This post is my initial results. I used the set of results which I had previously downloaded, so this includes papers up to some point in 2013.

When I came to go through the papers and categorise them it was obvious that some of my rankings may need adjusting, and that by the time I got a reasonable way through the process my initial thoughts on what the categories should include have changed. Basically, I'm just saying that this is a work in progress.

This is the table of topics:

Topic Earliest Latest Papers
Treatments 1984 2012 20
Clinical studies 1980 2012 93
Clinical and Genetic studies 1981 2013 51
Genetic studies 1996 2012 67
Genetic identification 1983 2013 241
Assessment tools 1975 2013 25
Reviews 1953 2013 34
Models 1998 2013 62
Biology 1976 2013 100
Prevalence 1985 2009 11
Multi-illness studies 1975 2013 113
Uncategorised 1946 2013 376

I've used the "biology" category as a bit of "not sure" category at times, so there may be a few papers in this topic which are not strictly to do with the biology of HSP. Other papers cover a few different topics, so there will be many papers which could easily be put into different categories.

I suspect that readers would be most interested in the treatment category. These papers comprise:

9 papers on Baclofen
3 papers on Botox
2 papers on Levodopa
1 paper each for: Gabapentin, Electrical stimulation, Progabide, Methylphenidate and Ranibizumab
There was one further paper which looked generally at matching drugs to diseases based on genetic analysis.

In addition to some of these papers, my most relevant papers covered:
Depression, bladder function, cognitive performance, sensory function, continence and the prevalence of HSP. All in all there are about 30 papers which I thought would be most useful.

This is how all of those categories look on a graph:

Next steps:

Create a page on this blog to hold such information
Add papers published since end of last trawl
Classify papers with ranks of 3 and below
Review classification and topic designations

Ultimately I'm aiming to draw out analysis for different aspect of HSP, but I'm a way off that yet.

No comments:

Post a Comment