Planning for clinical trials for HSP drug
Researchers in Australia are currently planning to start clinical trials for the candidate drug Noscapine, based on its effectiveness on HSP stem cells, safety data, toxicology data, patent status, availability, and future affordability to HSPers.https://hspersunite.org.au/hsp-research-program-update-march-2017/
https://hspersunite.org.au/promising-hsp-drugs-identified/
Oxybutynin link to dementia
It has been reported that there is a link between Oxybutynin and dementia. Oxybutynin is one of the common over-active-bladder medications. Readers who take bladder medication may wish to check of oxybutynin is their active ingredient and perhaps discuss with their doctor.https://www.sciencedaily.com/releases/2017/03/170327083445.htm
Neurological conditions have impaired swallowing
This story caught my attention as various people with HSP have mentioned having difficulty swallowing. With impaired swallowing people are unable to protect their lungs in the way that a healthy person can, at risk for inhaling food and saliva into the lungs with various health consequences. Others may have impaired coughing or breathing. This reports that risk of swallowing difficulties can be predicted by weak cough for people with Parkinsons. A number of therapies are being developed.https://theconversation.com/a-serious-and-often-overlooked-issue-for-patients-with-brain-diseases-swallowing-67042
Gut bacteria research looking at slowing down Motor Neurone Disease
Researchers from the Leonard Wolfson Experimental Neurology Centre (LWENC) have been awarded a grant to investigate how changes in gut bacteria could slow the progression of neurodegenerative disorders such as Motor Neurone Disease (MND). They will assess whether changes in gut microbiota (gut flora/bacteria) can influence cells in the brain that control inflammation and appear to be central in MND and other diseases like Alzheimer’s. The team believes the cells may be able to slow progression. HSP is a motor neurone disease. Results due 2021http://www.uclh.nhs.uk/News/Pages/ChangestogutbacteriacouldholdkeytoslowingdownMotorNeuroneDisease.aspx
Shared genetic origin for ALS/MND and schizophrenia
Researchers have shown that Amyotrophic Lateral Sclerosis (ALS), also known as Motor Neurone Disease (MND) and schizophrenia have a shared genetic origin. ALS/MND is not just a disorder of individual nerve cells, but a disorder of the way these nerve cells talk to one another as part of a larger network. So ALS/MND could be considered in the same way that we think about schizophrenia - a problem of disruptions in connectivity between different regions of the brain, and perhaps look for drugs to help stabilize the failing brain networks. There are similarities between ALS and HSP, so this might be relevant.
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